UPG-108

UPG-108, a peptide compound, is a non-competitive allosteric modulator of Urotensin II receptors (UTR) . UPG-108 significantly enhances the efficacy of UTR agonists but reduces the potency of UTR agonists. UPG-111 efficiently induces calcium release and does not cause contraction of rat aortic rings without endothelial denudation. UPG-111 can be used to study various diseases related to the angiotensinergic system[1].

3090686-88-4

12352209

Urotensin Receptor

GPCR/G Protein

Cancer; Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease

O=C([C@@H](NC([C@H](C(C)(SSC[C@H](NC([C@@H](NC([C@@H](NC1=O)CCCN)=O)CC2=CC=C(C=C2)O)=O)C(N[C@H](C(O)=O)C(C)C)=O)C)NC([C@H](CC(O)=O)NC([C@H]3N(CCC3)C([C@H]([C@H](O)C)NC([C@@H](N)CCC(N)=O)=O)=O)=O)=O)=O)CC4=CC=CC=C4)N[C@@H]1CC5=CNC6=CC=CC=C56

C65H88N14O17S2

1401.61

[1]Merlino F, et al. Expanding Structure-Activity Relationships of Human Urotensin II Peptide Analogues: A Proposed Key Role of the N-Terminal Region for Novel Urotensin II Receptor Modulators. J Med Chem. 2024 Aug 22;67 (16) :13879-13890.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P11258/

Peptides

No Development Reported