UPK1B-antilichaam

UPK1B Antibody: Uroplakin-1B (UPK1B) is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. UPK1B is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins and may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions.

7348

O75841

NP_008883

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Signal Transduction

UPK1B Antibody is affinity chromatography purified via peptide column.

Cat. No. 1305 - Human Kidney Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (100%)

UPK1B Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

UPK1B antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

At least two isoforms of UPK1B are known to exist; this antibody will recognize both isoforms. UPK1B antibody is predicted to not cross-react with other tetraspanin protein family members.

UPK1B

Uroplakin 1B

Homo sapiens

Yu J, Lin JH, Wu XR, et al. Uroplakins Ia and Ib, two major differentiation products of bladder epithelium, belong to a family of four transmembrane domain (4TM) proteins. J. Cell Biol. 1994; 125:171-82.

Wu XR, Kong XP, Pellicer A, et al. Uroplakins in urothelial biology, function, and disease. Kidney Int. 2009; 75:1153-65

Sun TT, Zhao H, Provet J, et al. Formation of asymmetric unit membrane during urothelial differentiation. Mol. Biol. Rep. 1996; 23:3-11.

UPK1B Antibody: UPIB, UPK1, TSPAN20, Uroplakin-1b, Tetraspanin-20, UP1b

ELISA, WB, IHC-P, IF

49619237

Liquid