URMC-099
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
URMC-099 is a potent (IC50 = 14 nM), brain penetrant mixed-lineage kinase 3 inhibitor (MLK3) . It also potently inhibits FLT3 (4 nM in vitro, but 560 nM in vivo), LRRK2 (11 nM), and ABL1 (3 nM) .1 URMC-099 displayed neuroprotective effects in HIV-associated neurocognitive disorders2 and facilitated microglial amyloid- degradation and clearance in mouse models.3,4 URMC-099 increased CD8+ T cells in mice and increased the CD8+GZMB+ T cell population in blood mononuclear cells isolated from breast cancer patients.5
Unconjugated
Off-white solid
-20°C
Beschrijving
URMC-099 Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
Specificaties
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