Uroguanyline (human) (TFA)

Uroguanylin (human) (TFA) is a natural ligand for the Guanylyl Cyclase (GCC) receptor expressed in metastatic colorectal cancer tumors. Uroguanylin (human) (TFA) has anti-tumor actions in an animal model for human colon cancer[1].

12352209

Guanylate Cyclase

GPCR/G Protein

Cancer-programmed cell death

Cancer

98.04

O=C([C@@H](N)CC(N)=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]1C)=O)C(C)C)=O)CC(N)=O)=O)C(C)C)=O)CSSC[C@H](N2)C(N[C@H](C(O)=O)CC(C)C)=O)=O)CC(C)C)=O)CCC(O)=O)=O)CSSC[C@H](NC1=O)C(N[C@H](C(NCC2=O)=O)[C@@H](C)O)=O)=O)CC(O)=O)=O)CC(O)=O.OC(C(F)(F)F)=O.[x]

C64H102N18O26S4.xC2HF3O2

1667.86 (free base)

[1]Lewis DK, et al. Hypertrehalosemic hormone in a cockroach: molecular cloning and expression. Mol Cell Endocrinol. 1997;130 (1-2) :101-108.

Blue Ice

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-P3099A/Uroguanylin-human-TFA-SDS-MedChemExpress.pdf

Peptides

No Development Reported