USP18 Antilichaam

The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15.

11274

Q9UMW8

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 200-300 of human USP18 (NP_059110.2) .

Unconjugated

Primary Antibodies

Cell Cycle

Affinity purification

HepG2

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 35kDa

IgG

WB: 1:500 - 1:2000

USP18

RAW264.7

Ubiquitin specific peptidase 18

Homo sapiens

USP18, ISG43, UBP43

WB

Liquid