USP20 Antilichaam - middengebied: Biotine (ARP59314 P050-Biotine)

Ubiquitin specific peptidase 20

VDU2, hVDU2, LSFR3A

10868

Q9Y2K6

NP_006667

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

The immunogen is a synthetic peptide directed towards the middle region of human USP20

USP20 is a deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling.USP20 acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2) . USP20 plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. USP20 deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity.USP20 mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

MDFI; MAGEA11; TRIM23; ALAS1; FATE1; BEND5; SPRY2; VAPB; CCDC36; BEND7; RAD17; NEURL4; USP33; USP20; CCP110; ADRB2; PJA1; USP28; USP21; USP15; PLA2G2A; UBC; VHL; HIF1A; VAPA; HERC2P2; PLEKHA7; SYTL4; GPT2; POLDIP3; RGPD5; ATAD3B; MAP7D1; LRRC59; ZNF770; S

Biotin

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 92%; Dog: 92%; Guinea Pig: 100%; Horse: 92%; Human: 100%; Mouse: 85%; Rabbit: 100%; Rat: 92%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

102kDa

Wet Ice

913

USP20

USP20

Rabbit

Ubiquitin carboxyl-terminal hydrolase 20

NM_006676

PAEAQPPSPRSSSPCRTPEPDNDAHLRSSSRPCSPVHHHEGHAKLSSSPP