UTX Antilichaam - C-terminal regio : HRP (ARP39483_P050-HRP)

Lysine (K) -specific demethylase 6A

UTX, KABUK2, bA386N14.2

7403

O15550

NP_066963

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

The immunogen is a synthetic peptide directed towards the middle region of human UTX

UTX is a histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. It demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. UTX plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitent with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A.

KMT2D; WDR5; ASH2L; RBBP5; SMAD9; HIST2H3C; SRF; SMARCA4; GATA4; NKX2-5; TBX5; UBC; HIST1H3A; WDR82; PAXIP1; NCOA6; TLE1; PROSER1; KMT2C; N4BP2; PPP6R3; ZNF281; HIST3H3

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

KDM6A is strongly supported by BioGPS gene expression data to be expressed in MCF7

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

154kDa

Hong, S., (2007) Proc. Natl. Acad. Sci. U.S.A. 104 (47), 18439-18444

Wet Ice

1401

KDM6A

KDM6A

Rabbit

Lysine-specific demethylase 6A

NM_021140

KTYIVHCQDCARKTSGNLENFVVLEQYKMEDLMQVYDQFTLAPPLPSASS