Vandetanib
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
443913-73-3
ZD6474
C07467-25mg
VEGFR
Protein Tyrosine Kinase
CN1CCC (CC1) COC2=C (C=C3C (=C2) N=CN=C3NC4=C (C=C (C=C4) Br) F) OC
C22H24BrFN4O2
Vandetanib is a potent inhibitor of VEGFR2 with IC50 of 40 nM in a cell-free assay. It also inhibits VEGFR3 and EGFR with IC50 of 110 nM and 500 nM, respectively. Not sensitive to PDGFRβ, Flt1, Tie-2 and FGFR1 with IC50 of 1.1-3.6 μM. No activity against MEK, CDK2, c-Kit, erbB2, FAK, PDK1, Akt and IGF-1R with IC50 above 10 μM. Vandetanib (ZD6474) increases apoptosis and induces autophagy by increasing the level of reactive oxygen species (ROS) .
2 years -80 in solvent
Beschrijving
Vandetanib Beschikbaar in 25 mg. Wordt geleverd met droogijs. Bestel eenvoudig online met snelle levering.
Specificaties
Recent bekeken producten
MicroMolar UDP assay kit - 100 assays
MUD100K
100 Assays
MEM Amino Acids Solution (50x) w/o: L-Glutamine
P08-30100
100 mL
White glass slide, frosted
1380-20
1440/CS
Anti-TNF-α (Adalimumab), humanized Antibody
A1048-100
100 µg
PEPTIC DIGEST OF ANIMAL TISSUE (MEAT PEPTONE)
P16-102-01
500 g
GelRed® Agarose LE
#41029-5G
1x 5 g
HT115 (DE3) Super Competent Cells
D1045S
10x 100 μL
HT115
ACC-130
10 Tubes
Recent gezochte producten
MicroMolar UDP assay kit - 100 assays
MUD100K
100 Assays
Glyoxalase I Activity Assay Kit (Colorimetric)
K591-100
100 Assays
Methylglyoxal Assay Kit (Colorimetric)
K500-100
100 Assays
Methanol Assay Kit (Colorimetric)
K898-100
100 Assays
PicoProbeTM Methylglyoxal Assay Kit (Fluorometric)
K461-100
100 Assays
Chlorine (Cl) Assay Kit (Colorimetric)
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96 Tests
ATP Assay Kit (Colorimetric)
NBP3-24473
96 Tests
Alcohol Assay Kit (Colorimetric)
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100 Assays