Vatalanib-d4

Vatalanib-d4 (PTK787-d4; ZK-222584-d4; CGP-79787-d4) is the deuterium labeled Vatalanib. Vatalanib (PTK787; ZK-222584; CGP-79787) is an inhibitor of VEGFR2/KDR with IC50 of 37 nM.

1246820-27-8

PTK787-d4; ZK-222584-d4; CGP-79787-d4

12352005

Isotope-Labeled Compounds; VEGFR

Others; Protein Tyrosine Kinase/RTK

Cancer

ClC(C([2H])=C1[2H])=C(C([2H])=C1NC2=NN=C(C3=CC=CC=C32)CC4=CC=NC=C4)[2H]

C20H11D4ClN4

350.84

[1]Wood JM, et al. PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res. 2000, 60 (8|[2]Murakami M, et al. Tyrosine kinase inhibitor PTK/ZK enhances the antitumor effects of interferon-α/5-fluorouracil therapy for hepatocellular carcinoma cells. Ann Surg Oncol. 2011, 18 (2), 589-596.|[3]Wan J, et al. Local recurrence of small cell lung cancer following radiofrequency ablation is induced by HIF-1α expression in the transition zone. Oncol Rep. 2016 Mar;35 (3) :1297-308.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W701071/

Isotope-Labeled Compounds

No Development Reported