Vav 1 oncogen Adenovirus (Ad-VAV1)
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Guanine nucleotide exchange factors (GEFs) regulate the activity of the small GTP-binding proteins of the Ras superfamily. The Ras family of proteins participate in a diverse array of functions, including signal transduction, cytoskeleton dynamics and intracellular trafficking. Ras proteins cycle between a biologically inactive GDP-bound state and an active GTP-bound state. GEFs catalyze the release of GDP from inactive Ras proteins to enable GTP binding. They include Vav, Vav2, Sos1, Sos2, RCC1, RhoGEF p115, Tiam1, Tiam2, Ral GDS, Ras-GRF1, Ras-GRF2, RasGRP, C3G, FGD1, FGD2, FGD3, NET1, Lbc, Lfc, Lsc, Ost, Frabin, Brx, Dble, Gem and Ect2. Vav has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.
Vav 1 oncogene Adenovirus
41106621
3822190000
Pre-Made
Dry Ice
-80C
12 Months
Ad-VAV1
Human Adenovirus Type5 (dE1/E3)
CMV (ubiquitous)
DMEM, 2% BSA, 2.5% Glycerol
1x10^10 PFU/ml
Beschrijving
Guanine nucleotide exchange factors (GEFs) regulate the activity of the small GTP-binding proteins of the Ras superfamily. The Ras family of proteins participat
Specificaties
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Horse Polyclonal Horse anti-Goat IgG ImmPRESS(TM) Secondary Antibody [HRP Polymer]
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Horse Polyclonal Horse anti-Mouse IgG ImmPRESS(TM) Secondary Antibody [AP Polymer]
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