VDR Antilichaam - N-terminaal gebied: Biotine (ARP31243_P050-Biotine)

Vitamin D (1,25- dihydroxyvitamin D3) receptor

NR1I1, PPP1R163

7421

P11473

NP_000367

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Zebrafish

The immunogen is a synthetic peptide directed towards the N terminal region of human VDR

The nuclear hormone receptor for vitamin D3 also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding the same protein.

MED12; MED24; BAZ1B; SMARCA4; RXRA; MED1; NCOA2; NSD1; NCOA1; SRPK1; PTPN3; Hr; NKD2; MMRN2; CDCA7L; CXXC5; UBC; RXRB; PRKCSH; PRCP; CFH; CCND3; MYC; MXD1; BRCA1; PSMC5; NCOR1; SRC; NCOA6; PPP1CC; CDK11B; NR1H2; RXRG; CASC4; GABARAPL1; GABARAPL2; CLASRP

Biotin

Polyclonal Antibody

WB

Affinity Purified

There is BioGPS gene expression data showing that VDR is expressed in Jurkat

0.5 mg/ml

Cow: 86%; Dog: 100%; Guinea Pig: 85%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 79%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

48kDa

Wet Ice

427

VDR

VDR

Rabbit

Vitamin D3 receptor

NM_000376

LKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPV