VE-Cadherine (fosfo Tyr731) Antilichaam

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen.

1003

P33151

NP_001786.2

Human, Mouse

VE-Cadherin (phospho Tyr731) antibody was raised against a peptide sequence around phosphorylation site of Tyrosine731 (H-I-Y (p) -G-Y) derived from Human VE-Cadherin.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

130 kDa

IgG

The antibody detects endogenous level of VE-Cadherin only when phosphorylated at tyrosine 731.

Western Blot: 1:500~1:1000

CDH5

Cadherin 5, type 2 (vascular endothelium)

Homo sapiens

Wessel F, et al. (2014) Nat Immunol 15, 223-30

Sawada J, et al. (2012) Cancer Cell 22, 235-49

Turowski P, et al. (2008) J Cell Sci 121, 29-37

Vascular endothelial cadherin, VE-cadherin, 7B4 antigen, CDH5, CD144 antigen

WB

166362713

Liquid