VEGF-B Aanbevolen eiwit

VEGF-B, a member of the VEGF family, is a potent growth and angiogenic cytokine. It promotes DNA synthesis in endothelial cells, helps regulate angiogenesis and vascular permeability, and inhibits apoptosis in certain smooth muscle cells and neurons. VEGF-B is expressed in all tissues except the liver. It forms cell surfaced-associated disulfide linked homodimers and can form heterodimers with VEGF-A. There are two known isoforms, formed by alternative splicing, which have been designated VEGF-B167 and VEGF-B186. Both forms have identical amino-terminal sequences encoding a "cysteine knot” like structural motif, but differ in their carboxyl-terminal domains. Both VEGF-B isoforms signal only through the VEGFR1 receptor. Recombinant human VEGF-B is a 38.0 kDa disulfide-linked homodimeric protein consisting of two 167 amino acid polypeptide chains.

7423

P49765

NP_001230662.1

Recombinant Proteins

E. coli

Cancer, Neuroscience, Signal Transduction

Room Temp

The lyophilized VEGF-B recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted VEGF-B is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing VEGF-B recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Vascular endothelial growth factor B

Homo sapiens

VRF, VEGFL, VRF, Vascular endothelial growth factor B, VEGF-related factor, VEGF-B

Human

344179103

Lyophilized