VEGFR-1 Antilichaam / FLT1

Vascular endothelial growth factor receptor 1 is a protein that in humans is encoded by the FLT1 gene. This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig) -like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.

Western blot: 0.5-1 µg/mL, ELISA: 0.1-0.5 µg/mL

P17948

Human

An E.coli-derived human recombinant protein (amino acids S27-R73) was used as the immunogen for the VEGFR-1 antibody.

WB, ELISA

Antigen affinity purified

Antigen affinity purified

Lyophilized from 1X PBS with 2% Trehalose

This VEGFR-1 antibody is available for research use only.

After reconstitution, the VEGFR-1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

0.5 mg/mL if reconstituted with 0.2ml sterile DI water

Optimal dilution of the VEGFR-1 antibody should be determined by the researcher.

Western blot testing of human placental tissue lysate with VEGFR-1 antibody. Predicted molecular weight ~150 kDa but may be observed at higher molecular weights due to glycosylation.