VENTX Antilichaam

VENTX Antibody: Lymphoid-enhancing factor/T-cell factors (LEF1/TCF) are a high-mobility group of transcriptional factors that play essential roles in cell fate determination during early embryogenesis and ontogenesis. VENTX is a member of the Vent family of homeodomain proteins. It is a novel LEF/TCF-associated transcriptional modulator. VENTX is predominately expressed in hematopoietic cells. VENTX may function as a transcriptional repressor and be involved in mesodermal patterning and hemapoietic stem cell maintenance, and has been suggested to have a potential role in the hematopoietic malignancies.

27287

O95231

NP_055283

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Stem Cell

VENTX Antibody is affinity chromatography purified via peptide column.

Cat. No. 1403 - Mouse Brain Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (92%), Chicken: (92%)

VENTX Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

VENTX antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

VENTX

VENT homeobox homolog (Xenopus laevis)

Homo sapiens

Reya T and Clevers H. Wnt signalling in stem cells and cancer. Nature2005; 434:843-50.

Moretti PA, Davidson AJ, Baker E, et al. Molecular cloning of a human Vent-like homeobox gene. Genomics2001; 76:21-9.

Gao H, Le Y, Wu X, et al. VentX, a novel lymphoid-enhancing factor/T-cell factor-associated transcription repressor, is a putative tumor suppressor. Cancer Res.2010; 70:202-11.

Shtutman M, Zhurinsky J, Simcha I, et al. The cyclin D1 gene is a target of the β -catenin/LEF-1 pathway. Proc. Natl. Acad. Sci. USA1999; 96:5522-7.

VENTX Antibody: NA88A, HPX42B, VENTX2, Homeobox protein VENTX, VENT homeobox homolog

ELISA, WB, IHC-P, IF

7657180

Liquid