Verlamelin A

Verlamelin A is a macrocyclic depsipeptide with antifungal and antiviral activity. Verlamelin A shows antifungal activity toward Aspergillus versicolor and Curvularia australiensis and also has antiviral activity toward HSV-1 (IC50 = 16.7 μM) . Verlamelin A is isolated from the entomopathogenic fungus Lecanicillium sp. Verlamelin A is useful for antifungal and antiviral research[1][2][3].

1619244-34-6

12352209

Fungal; HSV

Anti-infection

Infection

O=C1[C@@]2([H])N(C([C@H](NC([C@@](NC(CCC[C@@H](OC([C@@H](NC([C@H](NC([C@@H](N1)CCC(N)=O)=O)CC3=CC=C(C=C3)O)=O)C(C)C)=O)CCCCCCCCC)=O)([H])[C@H](O)C)=O)C)=O)CCC2

C45H71N7O11

886.09

[1]Ishidoh K, et al. Cyclic lipodepsipeptides verlamelin A and B, isolated from entomopathogenic fungus Lecanicillium sp. J Antibiot (Tokyo) . 2014 Jun;67 (6) :459-63.|[2]Sun X, et al. Total Synthesis of Verlamelin A and (5R) -Verlamelin A with Antifungal Activity. J Org Chem. 2025 Sep 5;90 (35) :12425-12434.|[3]Liang X, et al. Antifungal and Antiviral Cyclic Peptides from the Deep-Sea-Derived Fungus Simplicillium obclavatum EIODSF 020. J Agric Food Chem. 2017 Jun 28;65 (25) :5114-5121.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P11342/

Peptides

No Development Reported

HSV-1