VEZT Antilichaam

Vezatin (VEZT) is a transmembrane protein which localizes to adherens junctions and binds to myosin VIIA and the cadherin-catenins complex (1) . Expression of this gene in gastric cancer tissues is decreased due to hypermethylation of the promoter. Expression of this gene may also be inhibited by binding of a specific microRNA to a target sequence in the 3' UTR of the transcripts (2) . VEZT has also been shown to be required for morphogenesis of the preimplantation mouse embryo (3) .

55591

Q9HBM0

NP_060069

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Stem Cell

VEZT antibody is affinity chromatography purified via peptide column.

Cat. No. 1210 - HEK293 Cell Lysate

1 mg/mL

VEZT antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

VEZT antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

VEZT antibody is human, mouse and rat reactive. Multiple isoforms are known to exist.

VEZT

Vezatin, adherens junctions transmembrane protein

Homo sapiens

Kussel-Andermann P, El-Amraoui A, Safieddine S, et al. Vezatin, a novel transmembrane protein, bridges myosin VIIA to the cadherin-catenins complex. EMBO J. 2000; 19:6020-9.

Guo X, Jing C, Zhang L, et al. Down-regulation of VEZT gene expression in human gastric cancer involves promoter methylation and miR-43c. Biochem. Biophys. Res. Commun. 2011; 404:622-7.

Hyenne V, Louvet-Vallee S, El-Amraoui A, et al. Vezatin, a protein associated to adherins junctions, is required for mouse blastocyst morphogenesis. Dev. Biol. 2005; 287:180-91.

VEZT Antibody: VEZATIN, Vezatin

ELISA, WB, IHC-P, IF

155030244

Liquid