VGluT2 Antilichaam / Vesiculaire glutamaattransporter 2 / SLC17A6

VGluT2, short for Vesicular Glutamate Transporter 2, is a protein that is responsible for packaging and transporting glutamate into synaptic vesicles. These vesicles then release glutamate into the synaptic cleft, where it binds to receptors on the postsynaptic neuron, leading to the transmission of signals between neurons. Research has shown that VGluT2 is predominantly expressed in specific brain regions, such as the cerebellum, hippocampus, and cortex, where it plays a crucial role in modulating synaptic transmission and plasticity. Dysfunction of VGluT2 has been linked to various neurological disorders, including epilepsy, schizophrenia, and neurodegenerative diseases.

Western blot: 1:500-1:1000, Immunohistochemistry (FFPE) : 1:50-1:100

Q8BLE7

Mouse, Human

A portion of amino acids 507-535 from the mouse protein was used as the immunogen for the VGluT2 antibody.

WB, IHC-P

Antigen affinity

Purified

This VGluT2 antibody is available for research use only.

Aliquot the VGluT2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

In 1X PBS, pH 7.4, with 0.09% sodium azide

The stated application concentrations are suggested starting points. Titration of the VGluT2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

IHC staining of FFPE human brain tissue with VGluT2 antibody. HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to staining.