VHB937
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
VHB937 is a potent and selective TREM2 agonist, a human monoclonal antibody, with sub-nanomolar affinity. VHB937 enhances TREM2 surface expression and downstream signaling, such as Syk phosphorylation and calcium mobilization. VHB937 exhibits robust neuroprotective effects in vivo, significantly reducing pathology and pro-inflammatory markers across a broad range of animal models of neuroinflammation and neurodegeneration. VHB937 can be used for neurodegenerative diseases research[1].
12352211
Calcium Channel; Syk; TREM receptor
Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling; Protein Tyrosine Kinase/RTK
Inflammation/Immunology; Neurological Disease
99.9
[1]Stangel M, et al. VHB937, a TREM2 stabilizing and activating antibody strongly reduces pathology after peripheral administration in a broad range of animal models for neuroinflammation and neurodegeneration (P4-4.004) . Neurology. 2024;102 (7_supplement_1) .
Dry Ice
-80°C
http://file.medchemexpress.com/batch_PDF/HY-P991734/VHB937-SDS-MedChemExpress.pdf
Inhibitory Antibodies
No Development Reported
TREM-2
Beschrijving
VHB937 is a potent and selective TREM2 agonist, a human monoclonal antibody, with sub-nanomolar affinity. VHB937 enhances TREM2 surface expression and downstrea
Specificaties
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