VHL Antilichaam - N-terminaal gebied: Biotine (ARP59367 P050-Biotine)

Von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase

RCA1, VHL1, pVHL, HRCA1

7428

P40337-2

NP_937799

Human, Mouse, Rat, Cow, Dog, Guinea Pig

Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

ELC1; HIF1A; UBC; TPT1; MDFI; USP33; KAT2B; E2F1; TCP1; HSP90AA1; HSPA4; GLI1; EP300; SIRT1; AURKA; PARK7; RBX1; PDCD5; CUL2; TCEB2; TCEB1; AR; PIAS4; ILF3; HNRNPL; HNRNPA2B1; PRMT1; PRMT8; SON; SLC3A2; SLC2A1; RPS15A; RPL21; RPL5; HIST4H4; ACTB; VAPB; HI

Biotin

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 93%; Dog: 93%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rat: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

19kDa

Wet Ice

172

VHL

VHL

Rabbit

Von Hippel-Lindau disease tumor suppressor

NM_198156

EDGGEESGAEESGPEESGPEELGAEEEMEAGRPRPVLRSVNSREPSQVIF