VIMP Antilichaam

This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER) . It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) . Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR have been shown to function as modulators of Sec insertion in this protein (PMID:23614019) . An alternatively spliced transcript variant, lacking the SECIS element and encoding a non-Sec containing shorter isoform, has been described for this gene.

55829

Q9BQE4

Human, Mouse, Rat

A synthetic peptide corresponding to a sequence within amino acids 50-150 of human VIMP (NP_982298.2) .

Unconjugated

Primary Antibodies

Immunology, Innate Immunity, Signal Transduction

Affinity purification

293T

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 21kDa

IgG

WB: 1:500 - 1:2000

SELENOS

A-431

Mouse brain

Rat lung

VCP-interacting membrane protein

Homo sapiens

SELS, AD-015, ADO15, MGC104346, MGC2553, SBBI8, SEPS1, VIMP, SELS

WB

Liquid