Vinculine-antilichaam [8B5]

Vinculin is a cytoskeletal protein that plays an important role in the regulation of focal adhesions and embryonic development (1) . Three structural vinculin domains include an amino-terminal head, a short flexible proline-rich region and a carboxy-terminal tail (2) . Expression of vinculin were shown to be affected by the level of actin expression (2,3) . Vinculin deficiencies are associated with a decrease in cell adhesion and an increase in cell motility, suggesting a possible role in metastatic growth (4) . Defects in VCL are the cause of cardiomyopathy dilated type 1W (CMD1W) (5) .

7414

NP_003364

Human, Mouse, Rat, Rabbit, Chicken

Vinculin antibody was raised against a 23 amino acid peptide near the amino terminus of human Vinculin.

8B5

Unconjugated

Primary Antibodies

Homeostasis

Vinculin antibody is purified via Protein A prification.

Cat. No. 1216 - PC-3 Cell Lysate

1 mg/mL

Vinculin Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

Vinculin antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

Vinculin antibody is human, mouse, rat, rabbit and chicken reactive. At least three isoforms of Vinculin are known to exist.

VCL

Vinculin

Homo sapiens

Burridge et al. Annu. Rev. Cell Biol.1988; 4:487-525.

Gilmore et al. J. Cell Sci. 1992; 103:719-31.

Deakin et al. PLoS One 2012; 7:e37990.

Goldmann et al. Cell Biol. Int. 2013; Feb 1.

CMD1W, CMH15, Metavinculin, MVCL

ELISA, WB

4507877

Liquid