Vitronectine (VTN) (NM 000638) Humaan Recombinant Proteïne

The protein encoded by this gene functions in part as an adhesive glycoprotein. Differential expression of this protein can promote either cell adhesion or migration as it links cells to the extracellular matrix through a variety of ligands. These ligands include integrins, plasminogen activator inhibitor-1, and urokinase plasminogen activator receptor. This secreted protein can be present in the plasma as a monomer or dimer and forms a multimer in the extracellular matrix of several tissues. This protein also inhibits the membrane-damaging effect of the terminal cytolytic complement pathway and binds to several serpin serine protease inhibitors. This protein can also promote extracellular matrix degradation and thus plays a role in tumorigenesis. It is involved in a variety of other biological processes such as the regulation of the coagulation pathway, wound healing, and tissue remodeling. The heparin-binding domain of this protein give it anti-microbial properties. It is also a lipid binding protein that forms a principal component of high density lipoprotein. [provided by RefSeq, Aug 2020]

Purified recombinant protein of Human vitronectin (VTN), esidues 20-478aa, with N-terminal HIS tag, secretory expressed in HEK293, 50ug

V75; VN; VNT

7448

P04004, D9ZGG2

NM_000638

17q11.2

HEK293

N-His

ECM-receptor interaction, Focal adhesion

ECM-receptor interaction, Focal adhesion

>50 ug/mL as determined by microplate BCA method

> 90% as determined by SDS-PAGE and Coomassie blue staining

Liquid

PBS, pH7.4, 10% glycerol

Druggable Genome, Secreted Protein

52.2 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

VTN

Human

NP_000629

https://www.ncbi.nlm.nih.gov/gene/7448

https://www.uniprot.org/uniprot/P04004

https://www.ncbi.nlm.nih.gov/nuccore/NM_000638

https://www.ncbi.nlm.nih.gov/nuccore/NP_000629