Vm24-toxine (TFA)

Vm24-toxin (Vaejovis mexicanus peptide 24) TFA, a 36-residue peptide, is a potent and selective Kv1.3 blocker with a Kd of ~3 pM in lymphocytes. Vm24-toxin TFA shows >1500-fold affinity for Kv1.3 over other assayed potassium channels. Vm24-toxin TFA folds into a distorted cystine-stabilized α/β motif consisting of a single-turn α-helix and a three-stranded antiparallel β-sheet, stabilized by four disulfide bridges. Vm24-toxin TFA attenuates the CD4+ effector memory T cell response to T cell receptor (TCR) stimulation[1][2].

Vaejovis mexicanus peptide 24 (TFA)

12352209

Potassium Channel

Membrane Transporter/Ion Channel

COVID-19-immunoregulation

Cancer; Inflammation/Immunology

97.86

O=C([C@@H](N)C)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N1[C@H](C(N[C@H](C(N[C@H](C(N2[C@H](C(N3[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H]4CCCCN)=O)=O)CC(N)=O)=O)CCCCN)=O)CSSC[C@H](NC5=O)C(N)=O)=O)=O)CCC(N)=O)=O)C)=O)CCCNC(N)=N)=O)CSSC[C@H](NC6=O)C(N[C@H](C(N[C@H]5CC7=CC=C(O)C=C7)=O)CC8=CC=C(O)C=C8)=O)=O)CCCCN)=O)CCC3)=O)CCC2)=O)CSSC[C@H](NC9=O)C(N[C@H]6CCCCN)=O)=O)CCC(O)=O)=O)CCC1)=O)CO)=O)=O)C(C)C)=O)CSSC[C@H](NC4=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]9CCCCN)=O)CCCNC(N)=N)=O)CC(N)=O)=O)CCSC)=O)=O)CO)=O)[C@H](CC)C)=O)C)=O)C.OC(C(F)(F)F)=O.[x]

C157H253N51O45S9.xC2HF3O2

3863.59 (free base)

[1]Georgina B Gurrola, et al. Structure, function, and chemical synthesis of Vaejovis mexicanus peptide 24: a novel potent blocker of Kv1.3 potassium channels of human T lymphocytes. Biochemistry. 2012, 51, 19.|[2]Veytia-Bucheli JI, et al. Kv1.3 channel blockade with the Vm24 scorpion toxin attenuates the CD4+ effector memory T cell response to TCR stimulation. Cell Commun Signal. 2018 Aug 14;16 (1) :45.

Blue Ice

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-P5917A/

Peptides

No Development Reported

Voltage-gated potassium channel