Von Hippel Lindau (VHL) Mouse Monoclonal Antibody [Kloon ID: LBI1E1]

Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Carrier-free (BSA/glycerol-free) VHL mouse monoclonal antibody, clone LBI1E1

HRCA1; pVHL; RCA1; VHL1

Homo sapiens von Hippel-Lindau tumor suppressor (VHL), transcript variant 1, mRNA.

7428

P40337

Unconjugated

Pathways in cancer, Renal cell carcinoma, Ubiquitin mediated proteolysis

Pathways in cancer, Renal cell carcinoma, Ubiquitin mediated proteolysis

WB 1:4000, IHC 1:150

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Druggable Genome, Transcription Factors

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

VHL

https://www.ncbi.nlm.nih.gov/gene/?term=7428

https://www.uniprot.org/uniprot/P40337