VTCN1 Antilichaam

VTCN1 Antibody: T cell immunity plays a critical role in host immune surveillance of tumour cell growth and metastatic spread. VTCN1, also known as B7-H4, is a member of the B7 family of immune regulatory molecules. Expressed primarily on the membrane of lymphoid cells, VTCN1 is an immunoinhibitory protein that interacts with receptors on the surface of T lymphocytes, thus mediating cellular and humoral immune responses. Overexpression of VTCN1 is associated with certain malignancies, including ovarian and breast cancer, which may be a mechanism by which tumour cells suppress T cell immunity and facilitate tumour progression. VTCN1 may thus be a useful biomarker for the early detection of ovarian cancer.

79679

Q7Z7D3

NP_078902

Human, Mouse

Unconjugated

Primary Antibodies

Innate Immunity

VTCN1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1287 - EL4 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rat: (83%)

VTCN1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

VTCN1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Predicted: 31 kDa

IgG

VTCN1

V-set domain containing T cell activation inhibitor 1

Homo sapiens

Flies DB and Chen L. The new B7s: playing a pivotal role in tumor immunity. J. Immunother. 2007; 30:251-60.

Sica GL, Choi IH, Zhu G, et al. B7-H4, a molecule of the B7 family, negatively regulates T cell immunity. Immunity 2003; 18:849-61

Zang X, Loke P, Kim J, et al. B7x: a widely expressed B7 family member that inhibits T cell activation. Proc. Natl. Acad. Sci. USA 2003; 100:10388 - 92.

Salceda S, Tang T, Kmet M, et al. The immunomodulatory protein B7-H4 is overexpressed in breast and ovarian cancers and promotes epithelial cell transformation. Exp. Cell Res. 2005; 306:128-41.

VTCN1 Antibody: B7X, B7H4, B7S1, B7-H4, B7h.5, VCTN1, PRO1291, UNQ659/PRO1291, V-set domain-containing T-cell activation inhibitor 1, Immune costimulatory protein B7-H4

ELISA, WB

99028881

Liquid