VTI1a Antilichaam

Vesicle transport through interaction with t-SNAREs homolog 1 (VTI1a and VTI1b) are involved in vesicular transport from the late endosomes to the trans-Golgi network (1) . They are both localized in the trans-Golgi network, with VTI1a also found in the Golgi apparatus and VTI1b in endosomes (2,3) . VTI1a mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane and promotes fusion of the lipid bilayers (4) . VTI1a may be concerned with increased secretion of cytokines associated with cellular senescence (5) .

143187

Q96AJ9

NP_660207

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Homeostasis

VTI1a antibody is affinity chromatography purified via peptide column.

Cat. No. 1303 - Human Brain Tissue Lysate

1 mg/mL

VTI1a antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

VTI1a antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

VTI1a antibody is human, mouse and rat reactive. At least two isoforms of VTI1a are known to exist; this antibody will detect both isoforms. VTI1a antibody is predicted to not cross-react with VTI1b.

VTI1a

Cat. No. 10-301 - Human Brain Tissue Slide

Vesicle transport through interaction with t-SNAREs 1A

Homo sapiens

Fischer VM and Stevens TH. A human homolog can functionally replace the yeast vesicle-associated SNARE Vti1p in two vesicle transport pathways. J. Biol. Chem. 1998; 273:2624-30.

Kreykenbohm V, Wenzel D, Antonin W et al. The SNAREs vti1a and vti1b have distinct localization and SNARE complex partners. Eur. J. Cell Biol. 2002; 81:273-80.

Antonin W, Riedel D, von Mollard GF, et al. The SNARE Vti1a-beta is localized to small synaptic vesicles and participates in a novel SNARE complex. J. Neurosci. 2000; 20:5724-32.

Atlashkin V, Kreykenbohm V, Eskelinen EL, et al. Deletion of the SNARE vti1b in mice results in the loss of a single SNARE partner, syntaxin 8. Mol. Cell Biol. 2003; 23:5198-207.

Vesicle transport through interaction with t-SNAREs 1A, MMDS3, MVti1, VTI1RP2, Vti1-rp2

ELISA, WB, IHC-P

113374156

Liquid