VU661013
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
2131184-57-9
C13646-5mg
Bcl-2
Apoptosis
CC1CN (C (=O) C2=C (C3=C (N12) C (=C (C=C3) Cl) C4=C (N (N=C4C) C) C) CCCOC5=CC (=C (C (=C5) C) Cl) C) C6=CN (C7=C6C=C (C=C7) C (=O) O) C
C39H39Cl2N5O4
VU661013 is a novel, potent, selective MCL1 inhibitor with Ki of 97 ± 30 pM of human MCL-1 in a TR-FRET assay. However, VU661013 does not significantly inhibit BCL-xL or BCL-2 with Ki > 40 μM or = 0.73 μM. VU661013 de-stabilizes BIM/MCL-1 association, leads to apoptosis in AML.
3 years -20°C powder
Beschrijving
VU661013 Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
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