VX5
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
VX5 is a humanized IgG1κ monoclonal antibody inhibitor targeting BCA-1/CXCL13. VX5 significantly inhibits human CXCL13-mediated internalization of CXCR5, blocks both human and mouse CXCL13-dependent B-cells chemotaxis and migration (EC50s for 105 and 253 nM for human tonsillar and pre-B-697-hCXCR5 cells, respectively) . VX5 can be used to study autoimmune diseases like multiple sclerosis and arthritis, and cancers like gastric lymphomas and colon cancer[1].
VX5/5261
12352203
CXCR
GPCR/G Protein; Immunology/Inflammation
COVID-19-immunoregulation
Cancer; Inflammation/Immunology
96.19
[1]Klimatcheva E, et al. Anti-cxcl13 antibodies and associated epitope sequences. US20160002325A1. 2016-01-07.
Dry Ice
-80°C
http://file.medchemexpress.com/batch_PDF/HY-P991567/VX5-SDS-MedChemExpress.pdf
Inhibitory Antibodies
No Development Reported
Beschrijving
VX5 is a humanized IgG1κ monoclonal antibody inhibitor targeting BCA-1/CXCL13. VX5 significantly inhibits human CXCL13-mediated internalization of CXCR5, blocks
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