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Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases.

5604;5605

Q02750

NP_002746.1; NP_109587.1

Human, Mouse, Rat

MEK1/MEK2 (Ab-217/221) antibody was raised against a peptide sequence around aa.215~219/219~223 (I-D-S-M-A) derived from Human MEK1/MEK2.

Unconjugated

Primary Antibodies

Other

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

None

Blue Ice

Store antibody at -20˚ C for up to one year.

45 kDa

This antibody detects endogenous level of total MEK1/MEK2 protein.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

MAP2K1 MAP2K2

Mitogen-activated protein kinase kinase 1 / mitogen-activated protein kinase kinase 2

Homo sapiens

Shen R, et al. (2002) Mol Cell Biol; 22 (10) : 3230-3236Preisinger C, et al. (2005) EMBO J; 24 (4) : 753-765Laine P, et al. (2000) Biochem J; 349 (Pt 1) : 19-25Yaglom J, et al. (2003) Mol Cell Biol; 23 (11) : 3813-3824Dahan S, et al. (2002) Infect Immun; 70 (5) : 2304-2310

CFC3, MEK1, MKK1, MAPKK1, PRKMK1, GLUR2, ERK activator kinase 1/ERK activator kinase2, MAP kinase kinase 1/MAP kinase kinase 2, MAP2K1/MAP2K1, MAPK/ERK kinase 1/MAPK/ERK kinase 2, MAPKK 1/MAPKK 1

WB, IHC, IF

5579478 / 13489054

Liquid