WAC Antilichaam

WAC Antibody: The WW domain containing adaptor with coiled-coil protein (WAC) contains a WW domain that mediates protein-protein interactions and colocalizes with RNA splicing factor SC35. Further studies have indicated that WAC is a functional partner of the RNF20/40 complex that ubiquitinates Histone H2B, and that WAC regulates H2B ubiquitination. WAC targets RNF20/40 to associate with RNA polymerase II complex for H2B ubiquitination at active transcription sites. WAC-dependent transcription is also important for cell-cycle checkpoint activation in response to genotoxic stress.

51322

Q9BTA9

NP_057712

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Cancer, Cell Cycle

WAC Antibody is affinity chromatography purified via peptide column.

Cat. No. 1313 - Human Testis Tissue Lysate

1 mg/mL

WAC Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

WAC antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

At least two isoforms of WAC are known to exist; this antibody will detect the larger isoform.

WAC

WW domain containing adaptor with coiled-coil

Homo sapiens

Xu GM and Arnaout MA. WAC, a novel WW domain-containing adapter with a coiled-coil region, is colocalized with splicing factor SC35. Genomics 2002; 79:87-94.

Zhang F and Yu X. WAC, a functional partner of RNF20/40, regulates histone H2B ubiquitination and gene transcription. Mol. Cell 2011; 41:384-97.

WAC Antibody: Wwp4, BM-016, PRO1741, KIAA1844, WW domain-containing adapter protein with coiled-coil

ELISA, WB, IHC-P, IF

18379328

Liquid