WAPL Antilichaam

WAPL (wings apart-like), also known as WAPAL or FOE, is a 1,190 amino acid protein that contains one WAPL domain and may play an important role in cell growth (1) . It is expressed in an isoform dependent manner in heart, skeletal muscle (isoform 2) and uterine cervix tumor tissue (isoform 1) (1,2,4) . WAPL is involved in sister-chromatid adhesion and promotes release of cohesin from chromosomes by directly interacting with its regulatory subunits (3,4) . WAPL is a new regulator of the development and metastasis of cancerous tissue (4,5) .

23063

Q7Z5K2

NP_055860

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Homeostasis, Stem Cell

WAPL antibody is affinity chromatography purified via peptide column.

Cat. No. 1288 - A20 Cell Lysate

1 mg/mL

WAPL antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

WAPL antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

WAPL antibody is human, mouse and rat reactive. At least four isoforms of WAPL are known to exist.

WAPAL

Wings apart-like homolog (Drosophila)

Homo sapiens

Kwiatkowski BA, Ragoczy T, Ehly J, et al. Identification and cloning of a novel chromatin-associated protein partner of Epstein-Barr nuclear protein 2. Exp. Cell Res. 2004; 300:223-33.

Kueng S, Hegemann B, Peters BH, et al. Wapl controls the dynamic association of cohesion with chromatin. Cell 2006; 127:955-67.

Gandhi R, Gillespie PJ, and Hirano T. Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase. Curr. Biol. 2006; 16:2406-17.

Oikawa K, Ohbayashi T, Kiyono T, et al. Expression of a novel human gene, human wings apart-like (hWAPL), is associated with cervical carcinogenesis and tumor progression. Cancer Res. 2004; 64:3545-9.

WAPL Antibody: FOE, WAPL, KIAA0261, FOE, Wings apart-like protein homolog, Friend of EBNA2 protein

ELISA, WB, IHC-P, IF

42734325

Liquid