WAS Antilichaam

The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients.

7454

P42768

P42768

Human, Mouse

This WAS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 116-144 amino acids from the Central region of human WAS.

Unconjugated

Primary Antibodies

Signal Transduction

This antibody is purified through a protein A column, followed by peptide affinity purification.

Batch dependent

Supplied in PBS with 0.09% (W/V) sodium azide.

None

Blue Ice

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

53 kDa

Rabbit Ig

WAS

Wiskott-Aldrich syndrome protein

Homo sapiens

Rajmohan, R., et al. FEMS Yeast Res. 9 (8) :1226-1235 (2009)

Dovas, A., et al. J. Cell. Sci. 122 (PT 21), 3873-3882 (2009)

Cammer, M., et al. J. Biol. Chem. 284 (35) :23302-23311 (2009)

Zhang, J., et al. J. Biol. Chem. 284 (32) :21659-21669 (2009)

Wiskott-Aldrich syndrome protein, WASp, WAS, IMD2

WB, IHC-P, Flow

Liquid