WDR35 Antilichaam

WDR35 Antibody: WD40 repeats are a common structural module in eukaryotic proteins, and proteins containing WD40 domains have a wide range of functions, including signal transduction, cell cycle regulation, RNA splicing, and transcription. One such protein, WDR35, also known as CED2, has been shown to be mutated in patients with Sensenbrenner syndrome/cranioectodermal dysplasia (CED), an autosomal-recessive disease that is characterized by craniosynstosis and ectodermal and skeletal abnormalities. WDR35 localizes to cilia and dentrosomes during embryogenesis and human and mouse fibroblasts that lack this gene fail to produce cilia. Mutations in this gene can also cause short-rib polydactyly syndromes due to abnormal ciliogenesis.

57539

Q9P2L0

NP_001006658

Human

Unconjugated

Primary Antibodies

Stem Cell

WDR35 Antibody is affinity chromatography purified via peptide column.

Cat. No. 11-701 - Human Testis Tissue Slide

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rat: (94%), Mouse: (94%)

WDR35 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

WDR35 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

WDR35 antibody is human specific.

WDR35

WD repeat domain 35

Homo sapiens

Gilissen C, Arts HH, Hoischen A, et al. Exome sequencing identifies WDR35 variants involded in Sensenbrenner syndrome. Am. J. Hum. Genet. 2010; 87:418-23.

Mill P, Lockhart PJ, Fitzpatrick E, et al. Human and mouse mutations in WDR35 cause short-rib polydactyly syndromes due to abnormal ciliogenesis. Am J. Hum. Genet. 2011; 88:508-15.

WDR35 Antibody: CED2, IFTA1, SRTD7, IFT121, KIAA1336, WD repeat-containing protein 35, Intraflagellar transport protein 121 homolog

ELISA, IHC-P

55743161

Liquid