WDR61 Antilichaam

WDR61 (WD-repeat-containing protein 61), also known as SKI8 or REC14, is a subunit of the human PAF and SKI complexes, which function in transcriptional regulation and are involved in events downstream of RNA synthesis, such as RNA surveillance (1,2) . PAF1C is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1C (3,4) .

80349

Q9GZS3

NP_079510

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Stem Cell

WDR61 antibody is affinity chromatography purified via peptide column.

Cat. No. 1220 - SK-N-SH Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (93%), Chicken: (79%)

WDR61 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

WDR61 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

WDR61 antibody is human, mouse and rat reactive.

WDR61

WD repeat domain 61

Homo sapiens

Zhu B, Mandal SS, Pham AD, et al. The human PAF complex coordinates transcription with events downstream of RNA synthesis. Genes Dev. 2005; 19:1668-73.

Zhu B, Zheng Y, Pham AD, et al. Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. Mol. Cell. 2005; 20:601-11.

Kim J, Guermah M, and Roeder RG. The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS. Cell 2010; 140:491-503.

Chen Y, Yamaguchi Y, Tsugeno Y, et al. DSIF, the Paf1 complex, and Tat-SF1 have nonredundant, cooperative roles in RNA polymerase II elongation. Genes Dev. 2009; 23) :2765-77.

WD repeat-containing protein 61, Meiotic recombination REC14 protein homolog, REC14, SKI8

ELISA, WB, IHC-P, IF

13376840

Liquid