WDR77 Antilichaam - N-terminaal gebied: Biotine (ARP58692 P050-Biotine)

WD repeat domain 77

P44, MEP50, MEP-50, HKMT1069, Nbla10071, p44/Mep50

79084

Q9BQA1

NP_077007

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit

The immunogen is a synthetic peptide directed towards the N terminal region of human WDR77

WDR77 is the non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. WDR77 might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage.

TP53; CUL3; SMAD1; AR; UBC; ASB15; WWOX; ZBTB1; SMYD1; COPS4; COPS7A; DCAF8; COPS8; PRMT5; TBC1D4; EPB41L2; HGS; FBXO6; PAN2; SNRPC; PPP1R8; POLR2C; PCBP2; HNRNPM; GRB2; QKI; TOE1; PPIL1; SAP30BP; LSM3; GPKOW; SF3A1; SF3B4; RBM5; PQBP1; THOC1; AQR; BAG2

Biotin

Polyclonal Antibody

WB

Affinity Purified

WDR77 is strongly supported by BioGPS gene expression data to be expressed in HEK293T

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 93%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

38kDa

Wet Ice

342

WDR77

WDR77

Rabbit

Methylosome protein 50

NM_024102

MRKETPPPLVPPAAREWNLPPNAPACMERQLEAARYRSDGALLLGASSLS