Win 18446 (Standaard)
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Win 18446 is an orally active testes-specific enzyme ALDH1a2 inhibitor, with an IC50 of 0.3 μM. Win 18446 reversibly inhibits spermatogenesis in many species and inhibits Retinoic acid biosynthesis from Retinol (HY-B1342) within the testes[1][2].
1477-57-2
12352211
Aldehyde Dehydrogenase (ALDH)
Metabolic Enzyme/Protease
Endocrinology
O=C(NCCCCCCCCNC(C(Cl)Cl)=O)C(Cl)Cl
C12H20Cl4N2O2
366.11
[1]John K Amory, et al. Suppression of spermatogenesis by bisdichloroacetyldiamines is mediated by inhibition of testicular retinoic acid biosynthesis. J Androl. Jan-Feb 2011;32 (1) :111-9.|[2]Cathryn A Hogarth, et al. Suppression of Stra8 expression in the mouse gonad by WIN 18,446. Biol Reprod. 2011 May;84 (5) :957-65.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-W011094R/
Reference Standards
Beschrijving
Win 18446 is an orally active testes-specific enzyme ALDH1a2 inhibitor, with an IC50 of 0.3 μM. Win 18446 reversibly inhibits spermatogenesis in many species an
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