WKK 2 (fosfo-Tyr542) Antilichaam

Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus.

5781

Q06124

NP_002825.3

Human, Mouse, Rat

SHP-2 (Phospho-Tyr542) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 542 (H-E-Y (p) -T-N) derived from Human SHP-2.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

72 kDa

This antibody detects endogenous level of SHP-2 only when phosphorylated at tyrosine 542.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

PTPN11

Protein tyrosine phosphatase, non-receptor type 11

Homo sapiens

Ferjoux G, et al. (2003) Mol Biol Cell. 2003; 14 (9) : 3911-3928. Shi ZQ, et al. (2000) Mol Cell Biol. 20 (5) : 1526-1536. Li C, Friedman JM. (1999) Proc Natl Acad Sci U S A ; 96 (17) : 9677-9682Manes S, et al. (1999) Mol Cell Biol. 19 (4) : 3125-3135. Oh ES, et al. (1999) Mol Cell Biol; 19 (4) : 3205-3215.

CFC, NS1, SHP2, BPTP3, PTP2C, PTP-1D, SH-PTP2, SH-PTP3, FRAP, FRAP1, FRAP2, RAFT1, RAPT1, PTN11, PTP-2C, PTPN11

WB, IHC

33356177

Liquid