WKK2 Antilichaam

SHP2 Antibody: Src homology-2 domain containing protein (SHP2) is a member of the protein tyrosine phosphatase (PTP) family, a protein family that contains signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. SHP2 contains two tandem Src homology-2 (SH2) domains, which function as phosphotyrosine binding domains either directly or through scaffolding intermediates such as the insulin-receptor substrate 1 (IRS-1) . These SH2 domains mediate the interaction of SHP2 with its substrates, allowing SHP2 to dephosphorylate proteins that inhibit signaling kinases such as ERK1 and AKT. SHP2 is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Recent experiments have shown SHP2 plays a significant role in hepatoprotection and liver regeneration.

5781

Q06124

NP_002825

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Signal Transduction

SHP2 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1407 - Mouse Skeletal Muscle Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Chicken: (100%)

SHP2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

SHP2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

PTPN11

Protein tyrosine phosphatase, non-receptor type 11

Homo sapiens

Yu Z, Ahmad S, Schwartz JL, et al. Protein-tyrosine phosphatase SHP2 is positively linked to proteinase-activated receptor 2-mediated mitogenic pathway. J. Biol. Chem.1997; 272:7519-24.

Ostman A, Hellberg C, and Bohmer FD. Protein-tyrosine phosphatases and cancer. Nat. Rev. Cancer 2006; 6:307-20.

Bard-Chapeau EA, Yuan J, Droin N, et al. Concerted functions of Gab1 and Shp2 in liver regeneration and hepatoprotection. Mol/ Cell. Biol. 2006; 26:4664-74.

SHP2 Antibody: CFC, NS1, SHP2, BPTP3, PTP2C, PTP-1D, SH-PTP2, SH-PTP3, SHPTP2, Tyrosine-protein phosphatase non-receptor type 11, Protein-tyrosine phosphatase 1D

ELISA, WB, IF

33356177

Liquid