WKK2 Antilichaam / PTPN11

SHP2, also known as PTPN11, is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in the gene are a cause of Noonan syndrome as well as acute myeloid leukemia.

Western blot: 1:1000, IHC (Paraffin) : 1:50-1:100, Flow Cytometry: 1:10-1:50

Q06124

Human

A portion of amino acids 526-551 from the human protein was used as the immunogen for this SHP2 antibody.

WB, IHC, FACS, ELISA

Antigen affinity

Antigen affinity purified

This SHP2 antibody is available for research use only.

Aliquot the SHP2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

In 1X PBS, pH 7.4, with 0.09% sodium azide

Titration of the SHP2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Chicken, Mouse, Rat

Western blot analysis of SHP2 antibody and 1) 293, 2) K562 lysate. Predicted molecular weight: ~68kDa.