WKYMVM-NH2

187986-11-4

Others

Others

WKYMVM-NH2 is a hexapeptide that activates neutrophils and myeloid cells through the FPRL1 and FPRL2 receptors, with EC50 values of 2 nM for HL-60-FPRL1 cells and 80 nM for HL-60-FPRL2 cells. It also induces chemotaxis in HL-60 cells stably expressing FPRL2, with optimal migration observed at concentrations ranging from 10 to 50 nM. Additionally, WKYMVM-NH2 stimulates neutrophils to produce superoxide with an EC50 of 75 nM. It is applicable in research focused on inflammatory diseases.

C([C@@H](C(N[C@H](C(N[C@@H](CC1=CC=C(O)C=C1)C(N[C@H](C(N[C@H](C(N[C@@H](CCSC)C(N)=O)=O)[C@@H](C)C)=O)CCSC)=O)=O)CCCCN)=O)N)C=2C=3C(NC2)=CC=CC3

C41H61N9O7S2

856.109

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