Wnt10a Antilichaam

Wnt10a Antibody: Wnt10a is a member of the Wnt family, a gene family that encodes secreted signaling proteins that play crucial roles in normal development such as regulation of cell fate and patterning during embryogenesis as well as neoplastic transformation. Elevated levels of Wnt10a have been detected in several human tumors and cancer cell lines including colorectal cancer and chronic lymphocytic leukemia and it has been suggested that uncontrolled Wnt signaling may contribute to the defect in apoptosis that characterizes these malignancies. Recently, a mutation in Wnt10a was found to be associated with odonto-onycho-dermal dysplasia, an autosomal recessive ectodermal dysplasia.

80326

Q9GZT5

Q9GZT5

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Signal Transduction, Cancer

Wnt10a Antibody is affinity chromatography purified via peptide column.

Cat. No. 1283 - RAW 264.7 Cell Lysate

1 mg/mL

Wnt10a Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

Wnt10a antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

This Wnt10a antibody is predicted to not cross-react with Wnt10b.

WNT10A

Wingless-type MMTV integration site family, member 10A

Homo sapiens

Kelly GM, Lai CJ, and Moon RT. Expression of wnt10a in the central nervous system of developing zebrafish. Dev. Biol. 1993; 158:113-21.

Nusse R and Varmus RE. Wnt genes. Cell 1992; 69:1073-87.

Kirikoshi H, Sekihara H, and Katoh M. WNT10A and WNT6, clustered in human chromosome 2q35 region head-to-tail manner, are strongly coexpressed in SW480 cells. Biochem. Biophys. Res. Commun. 2001; 283:798-805.

Kirikoshi H, Inoue S, Sekihara H, et al. Expression of WNT10A in human cancer. Int. J. Oncol. 2001; 19:997-1001.

Wnt10a Antibody: OODD, SSPS, STHAG4, Protein Wnt-10a

ELISA, WB, IHC-P, IF

14424011

Liquid