WNT3 (NM 030753) Humaan Recombinant Proteïne

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region. [provided by RefSeq, Jul 2008]

Purified recombinant protein of Human wingless-type MMTV integration site family, member 3 (WNT3), with C-terminal DDK tag, secretory expressed in CHO cells, 20ug

INT4; TETAMS

7473

P56703

NM_030753

17q21.31-q21.32

CHO

C-DDK

Basal cell carcinoma, Hedgehog signaling pathway, Melanogenesis, Pathways in cancer, Wnt signaling pathway

Basal cell carcinoma, Hedgehog signaling pathway, Melanogenesis, Pathways in cancer, Wnt signaling pathway

>50 ug/mL as determined by Bradford protein assay

> 90% as determined by SDS-PAGE and Coomassie blue staining

Liquid

PBS, pH7.4, 10% glycerol

Druggable Genome, Secreted Protein, Transmembrane

37.4 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

WNT3

Human

NP_110380

https://www.ncbi.nlm.nih.gov/gene/7473

https://www.uniprot.org/uniprot/P56703

https://www.ncbi.nlm.nih.gov/nuccore/NM_030753

https://www.ncbi.nlm.nih.gov/nuccore/NP_110380