WWC1 Antilichaam

The WW and C2 domain containing 1 (WWC1) protein, also known as KIBRA, possesses two WW domains and an internal C2-like domain (1) . WWC1 was originally identified as a memory performance-associated protein in humans (2) and has recently been shown to be a novel regulator of the Hippo pathway (3) . WWC1 is phosphorylated by the mitotic kinases Aurora-A and –B (4), and in turn activates the Aurora kinases and is required for precise chromosome alignment during mitosis (5) .

23286

Q8IX03

NP_001155133

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Homeostasis, Neuroscience

WWC1 antibody is affinity chromatography purified via peptide column.

Cat. No. 1303 - Human Brain Tissue Lysate

1 mg/mL

WWC1 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

WWC1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

WWC1 antibody is human, mouse and rat reactive. At least three isoforms of WWC1 are known to exist; this antibody will detect all three isoforms.

WWC1

WW and C2 domain containing 1

Homo sapiens

Kremerskothen J, Plaas C, Buther K, et al. Characterization of KIBRA, a novel WW domain-containing protein. Biochem. Biophys. Res. Commun. 2003; 300:862-7.

Papassotiropoulos A, Stephan DA, Huentelman MJ, et al. Common Kibra alleles are associated with human memory performance. Science 2006; 314:475-8.

Genevet A, Wehr MC, Brain R, et al. Kibra is a regulator of the Salvador/Warts/Hippo signaling network. Dev. Cell 2010; 18:309-16.

Xiao L, Chen Y, Ji M, et al. KIBRA protein phosphorylation is regulated by mitotic kinase aurora and protein phosphatase 1. J. Biol. Chem. 2011; 286:36304-15.

WW and C2 domain containing 1, HBEBP3, HBEBP36, KIBRA, MEMRYQTL

ELISA, WB, IHC-P, IF

242247251

Liquid