XBP-1 Antilichaam (9B7E5]

XBP-1 Monoclonal Antibody: X box binding protein 1 (XBP-1) is a key protein in the mammalian unfolded protein response (UPR) that protects the cell against the stress of malfolded proteins in the endoplasmic reticulum (ER) . Upon sensing unfolded proteins, an ER transmembrane endonuclease and kinase termed IRE1p is activated and excises an intron from XBP-1 mRNA. The spliced XBP-1 mRNA results in a 371 amino acid protein (XBP-1s) which is then translocated to the nucleus where it binds to the regulatory elements of downstream genes. Together with other UPR transcription factors such as ATF6, XBP-1 stimulates the production of ER stress proteins including the ER resident protein chaperones glucose regulated protein (GRP) 78 and GRP94.

7494

P17861

BAB82982

Human, Mouse, Rat

Mouse monoclonal XBP-1 antibody was raised against recombinant protein corresponding to amino acids 2 to 160 of human XBP-1.

9B7E5

Unconjugated

Primary Antibodies

Signal Transduction

XBP-1 Monoclonal Antibody is immunoaffinity chromotography purified IgG.

Cat. No. 95-109 - XBP-1 Recombinant Protein

1 mg/mL

XBP-1 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

XBP-1 monoclonal antibody can be stored at -20˚ C, stable for one year.

IgG1, k

XBP1

Cat. No. 17-011 - Hep G2 Cell Slide

X-box binding protein 1

Homo sapiens

Yoshida H, Matsui T, Yamamoto T, et al. XBP1 mRNA is induced by ATF6 and spliced by IRE1p in response to ER stress to produce a highly active transcription factor. Cell 2001; 107:881-91.

Calfon M, Zeng H, Urano F, et al. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature 2002; 415:92-6.

Haze K, Yoshida H, Yanagi H, et al. Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic stress. Mol. Cell. Biol. 1999; 10:3787-99.

Little E, Ramakrishnan M, Roy B, et al. The glucose-regulated proteins (GRP78 and GRP94) : functions, gene regulation, and applications. Crit. Rev. Eukaryot. Gene Expr. 1994; 4:1-18.

XBP-1 Antibody [9B7E5] : XBP2, TREB5, XBP-1

ELISA, WB, ICC, IF

18148382

Liquid