XKR8 Antilichaam

The XK Kell blood group complex subunit-related family member 8 (XKR8) is a member of a family of proteins that promote the phagocytosis of dying cells by altering the phospholipid distribution of the plasma membrane (1) . XKR8 is thought to be a “scramblase”, an enzyme that eliminates the asymmetry of phospholipid distribution in the plasma membrane. In apoptotic cells, XKR8 promotes the cell-surface exposure of phosphatidylserine (PtdSer) which serves as a signal for phagocytosis (1,2) .

55113

Q9H6D3

NP_060523

Human

Unconjugated

Primary Antibodies

Apoptosis

XKR8 antibody is affinity chromatography purified via peptide column.

Cat. No. 1319 - Human Stomach Tissue Lysate

1 mg/mL

XKR8 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

XKR8 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

XKR8 antibody is human reactive. At least two isoforms are known to exist; this antibody will detect both isoforms.

XKR8

Cat. No. 10-801 - Human Stomach Tissue Slide

XK, Kell blood group complex subunit-related family, member 8

Homo sapiens

Suzuki J, Denning DP, Imanishi E, et al. Xk-related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells. Science 2013; 341:403-6.

Wang X, Wu YC, Fadok VA, et al. Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12. Science 2003; 302:1563-6.

XKR8 Antibody: XRG8, hXkr8, XRG8, XK-related protein 8

ELISA, WB, IHC-P, IF

24431977

Liquid