XL541
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
XL541 is a potent, selective S1P1 antagonist. XL541 inhibits GDP-GTP exchange. XL541 causes frank surface hemorrhaging of tumors. XL541 collaborates with Paclitaxel to exhibit antitumor activity against breast cancer and lung cancer[1].
1221878-06-3
12352005
LPL Receptor
GPCR/G Protein
Cancer
FC1=CC=C(OC2=CC=C(NC([C@H]3N(C(CN4C=CN=N4)=O)C[C@H](CC5=CC=C(F)C=C5)C3)=O)C=C2)C=C1
C28H25F2N5O3
517.53
[1]Shankar G. Abstract# 3394: Selective disruption of tumor vessel architecture via inhibition of S1P1 with a novel small molecule, XL541. Cancer Research, 2009, 69 (9_Supplement) : 3394-3394.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-18165/
Reference compound1
No Development Reported
Beschrijving
XL541 is a potent, selective S1P1 antagonist. XL541 inhibits GDP-GTP exchange. XL541 causes frank surface hemorrhaging of tumors. XL541 collaborates with Paclit
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