XmAb5485
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
XmAb5485 is an Fc-engineered humanized anti-CD40 monoclonal antibody with high affinity to Fc-γ receptors. XmAb5485 induces potent antibody-dependent cell-mediated cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP) against tumor cells. XmAb5485 inhibits proliferation and induces apoptosis of tumor cells. XmAb5485 shows highly cytotoxic against lymphoma, leukemia and multiple myeloma cell lines as well as primary cancer cells[1].
12352203
Apoptosis; TNF Receptor
Apoptosis
Cancer-programmed cell death
Cancer
[1]Eugene A. Zhukovsky, et al. An Fc-Engineered Humanized Anti-CD40 Monoclonal Antibody, XmAb5485, Exhibits Potent Activity in Vitro and in Vivo against Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia and Multiple Myeloma, Blood, Volume 112, Issue 11, 2008, Page 881.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-P991555/
Inhibitory Antibodies
No Development Reported
Beschrijving
XmAb5485 is an Fc-engineered humanized anti-CD40 monoclonal antibody with high affinity to Fc-γ receptors. XmAb5485 induces potent antibody-dependent cell-media
Specificaties
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Hsa-miR-1258 miRNA Mimic
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Hsa-miR-4258 miRNA Agomir
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