Y-27632-d4 (hydrochloridehydraat)

Y-27632-d4 hydrochloride hydrate is the deuterium labeled Y-27632 hydrochloride hydrate. Y-27632 hydrochloride hydrate is an orally active, ATP-competitive inhibitor of ROCK-I and ROCK-II, with Kis of 220 and 300 nM, respectively. Y-27632 hydrochloride hydrate attenuates Doxorubicin-induced apoptosis of human cardiac stem cells. Y-27632 hydrochloride hydrate also suppresses dissociation-induced apoptosis of murine prostate stem/progenitor cells. Y-27632 hydrochloride hydrate primes human induced pluripotent stem cells (hIPSCs) to selectively differentiate towards mesendodermal lineage via epithelial-mesenchymal transition-like modulation[1][2][3][4][5][6][7].

12352005

Apoptosis; Isotope-Labeled Compounds; ROCK

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Others; Stem Cell/Wnt; TGF-beta/Smad

Cancer-Kinase/protease

Cancer

O=C([C@H]1CC[C@@](CC1)([C@H](N)C)[H])NC2=C([2H])C([2H])=NC([2H])=C2[2H].O.Cl.Cl

C14H21D4Cl2N3O2

342.30

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W700452/

Isotope-Labeled Compounds

No Development Reported