YAP (fosfo Ser127) Antilichaam

Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact.

10413

P46937

NP_001123617.1

Human, Mouse, Rat

YAP (phospho Ser127) antibody was raised against a peptide sequence around phosphorylation site of serine127 (A-H-S (p) -S-P) derived from Human YAP .

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

65 kDa

IgG

The antibody detects endogenous level of YAP only when phosphorylated at serine 127.

Western Blot: 1:500~1:1000

YAP1

Yes-associated protein 1

Homo sapiens

Sorrentino G, et al. (2014) Nat Cell Biol 16, 357-66

Yang S, et al. (2014) Cell Signal 26, 343-51

Sun W, et al. (2014) Mol Biol Rep 41, 947-56

YAP65, YAP1

WB

194306653

Liquid